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Clinical and Vaccine Immunology, July 2008, p. 1134-1137, Vol. 15, No. 7
1071-412X/08/$08.00+0     doi:10.1128/CVI.00091-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Modified Caspase-3 Assay Indicates Correlation of Caspase-3 Activity with Immunity of Nonhuman Primates to Yersinia pestis Infection{triangledown}

Susan Welkos,1* Sarah Norris,2 and Jeffrey Adamovicz3

Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702,1 Biostatistical Services Division, USAMRIID, Frederick, Maryland 21702,2 Midwest Research Institute, Frederick, MD 217023

Received 14 March 2008/ Returned for modification 17 April 2008/ Accepted 8 May 2008

Defined candidate human vaccines for treating infection by Yersinia pestis, the agent of plague, have been developed. To facilitate evaluation of the vaccines' efficacy, the in vitro caspase-3 assay for cytotoxicity-neutralizing activity was modified and reevaluated. Immune serum-mediated caspase-3 neutralizing activity correlated with protection against infection in a nonhuman primate vaccine model of plague immunity.

* Corresponding author. Mailing address: Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD 21702. Phone: (301) 619-4930. Fax: (301) 619-2152. E-mail: susan.welkos{at}amedd.army.mil

{triangledown} Published ahead of print on 14 May 2008.

Clinical and Vaccine Immunology, July 2008, p. 1134-1137, Vol. 15, No. 7
1071-412X/08/$08.00+0     doi:10.1128/CVI.00091-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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