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Clinical and Vaccine Immunology, June 2008, p. 1028-1030, Vol. 15, No. 6
1071-412X/08/$08.00+0     doi:10.1128/CVI.00026-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Enhancement of Diagnostic Efficiency by a Gamma Interferon Release Assay for Pulmonary Tuberculosis{triangledown}

Kelly Aparecida Kanunfre,1 Olavo Henrique Munhoz Leite,2 Max Igor Lopes,2 Marcelo Litvoc,2 and Antonio Walter Ferreira1,3*

Laboratory of Seroepidemiology and Immunobiology, Instituto de Medicina Tropical de São Paulo, University of São Paulo, São Paulo, Brazil,1 Clinic for Infectious Diseases of the Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil,2 Department of Infectious and Parasitic Diseases, School of Medicine, University of São Paulo, São Paulo, Brazil3

Received 21 January 2008/ Returned for modification 16 February 2008/ Accepted 1 April 2008

This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to ≥0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.

* Corresponding author. Mailing address: Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar 470, 05403-000 São Paulo, Brazil. Phone: 55 11 3061 7022. Fax: 55 11 3061 8270. E-mail: clawsmbf{at}usp.br

{triangledown} Published ahead of print on 9 April 2008.

Clinical and Vaccine Immunology, June 2008, p. 1028-1030, Vol. 15, No. 6
1071-412X/08/$08.00+0     doi:10.1128/CVI.00026-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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