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Clinical and Vaccine Immunology, June 2008, p. 1024-1027, Vol. 15, No. 6
1071-412X/08/$08.00+0     doi:10.1128/CVI.00009-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Immunoglobulin G Avidities in Infants in Mexico after Primary Immunization with Three Doses of Polyribosylribitol Phosphate-Tetanus Toxoid Haemophilus influenzae Type b Vaccine{triangledown} ,{dagger}

Patricia Gómez-de-León,1* F. Javier Díaz-García,1 Alberto Villaseñor-Sierra,2 Jorge Segura,3 Martha I. Carranza,2 José Luis Arredondo-Garcia,3 and José Ignacio Santos4,5

Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., México,1 Laboratorio de Microbiología Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México,2 Dirección de Investigación Clínica, Instituto Nacional de Pediatría, Secretaría de Salud, México D.F., México,3 Hospital Infantil de México Federico Gómez, Secretaría de Salud, México D.F., México,4 Departamento de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., México5

Received 9 January 2008/ Returned for modification 8 February 2008/ Accepted 8 April 2008

Serum immunoglobulin G concentrations and avidities specific to Haemophilus influenzae type b (Hib) were measured in 208 children living in Guadalajara and Mexico City. Protective concentrations were found in 98.9% and 100.0% of participants, respectively. Geometric mean concentrations differed between both populations and/or among age groups. Mean avidities differed only among the 7- to 12-month-old children. Diphtheria-tetanus-whole-cell pertussis-hepatitis B-Hib primary vaccination seems to induce protection in Mexican children.

* Corresponding author. Mailing address: Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Edificio de Investigación 3er. Piso, México D.F. 04510, México. Phone and fax: (52 55) 56 23 2249. E-mail: pglc{at}servidor.unam.mx

{triangledown} Published ahead of print on 16 April 2008.

{dagger} Supplemental material for this article may be found at http://cvi.asm.org/.

Clinical and Vaccine Immunology, June 2008, p. 1024-1027, Vol. 15, No. 6
1071-412X/08/$08.00+0     doi:10.1128/CVI.00009-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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