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Clinical and Vaccine Immunology, June 2008, p. 1019-1023, Vol. 15, No. 6
1071-412X/08/$08.00+0     doi:10.1128/CVI.00203-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

LruA and LruB Antibodies in Sera of Humans with Leptospiral Uveitis{triangledown}

Ashutosh Verma,1,{dagger} S. R. Rathinam,2 C. Gowri Priya,3 V. R. Muthukkaruppan,3 Brian Stevenson,4 and John F. Timoney1*

M. H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, Kentucky 40546,1 Uvea Clinic, Aravind Eye Hospital, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India,2 Aravind Medical Research Foundation, No. 1, Anna Nagar, Madurai 625 020, Tamil Nadu, India,3 Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, Kentucky 405364

Received 17 May 2007/ Returned for modification 10 August 2007/ Accepted 1 April 2008

Uveitis can be a serious complication of leptospirosis. Previous studies indicated that the leptospiral lipoproteins LruA and LruB are expressed in the eyes of uveitic horses and that antibodies directed against those proteins show in vitro cross-reactivity with components of equine lens, ciliary body, and/or retina. We now demonstrate that sera from a significant proportion of humans who have leptospiral uveitis also contain antibodies against LruA and LruB. Different categories of nonleptospiral uveitis and autoimmune uveitis were also screened; patients diagnosed with Fuchs uveitis or Behçet's syndrome produced antibodies that cross-reacted with LruA and LruB, suggesting similarities of the autoimmune responses in those diseases with those of leptospiral uveitis.

* Corresponding author. Mailing address: 325 M. H. Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546. Phone: (859) 257-4757, ext. 81106. Fax: (859) 257-5619. E-mail: jtimoney{at}uky.edu

{triangledown} Published ahead of print on 9 April 2008.

{dagger} Present address: Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, College of Medicine, Lexington, KY 40536.

Clinical and Vaccine Immunology, June 2008, p. 1019-1023, Vol. 15, No. 6
1071-412X/08/$08.00+0     doi:10.1128/CVI.00203-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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