CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
CVI.00035-08v1
15/5/885    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Klingström, J.
Right arrow Articles by Ahlm, C.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klingström, J.
Right arrow Articles by Ahlm, C.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, May 2008, p. 885-887, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00035-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Sex-Dependent Differences in Plasma Cytokine Responses to Hantavirus Infection{triangledown}

Jonas Klingström,1,2,3* Therese Lindgren,1 and Clas Ahlm1

Department of Clinical Microbiology, Division of Infectious Diseases, Umeå University, SE-901 85 Umeå, Sweden,1 Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden,2 Centre for Microbiological Preparedness, Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden3

Received 25 January 2008/ Returned for modification 7 February 2008/ Accepted 11 March 2008

There are often sex differences in susceptibility to infectious diseases and in level of mortality after infection. These differences probably stem from sex-related abilities to mount proper or unwanted immune responses against an infectious agent. We report that hantavirus-infected female patients show significantly higher plasma levels of interleukin-9 (IL-9), fibroblast growth factor 2, and granulocyte-macrophage colony-stimulating factor and lower levels of IL-8 and gamma interferon-induced protein 10 than male patients. The results demonstrate that a virus infection can induce sex-dependent differences in acute immune responses in humans. This finding may, at least partly, explain the observed sex differences in susceptibility to infectious diseases and in mortality following infection.

* Corresponding author. Mailing address: Swedish Institute for Infectious Disease Control, SE-171 82 Solna, Sweden. Phone: 4684572574. Fax: 468307957. E-mail: Jonas.Klingstrom{at}smi.ki.se

{triangledown} Published ahead of print on 19 March 2008.

Clinical and Vaccine Immunology, May 2008, p. 885-887, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00035-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.