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Clinical and Vaccine Immunology, May 2008, p. 859-862, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00471-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Major Outer Membrane Proteins from Many Campylobacter Species Cross-React with Cholera Toxin{triangledown}

M. John Albert,1* Shilpa Haridas,1 and Ben Adler2,3

Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait,1 Australian Bacterial Pathogenesis Program,2 ARC Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, Victoria 3800, Australia3

Received 27 November 2007/ Returned for modification 28 January 2008/ Accepted 9 March 2008

We have previously shown that Campylobacter jejuni strains do not produce a functional cholera toxin-like toxin (CTLT) detectable in a Chinese hamster ovary cell assay. Instead, the 53-kDa major outer membrane protein (OMP) of C. jejuni, PorA, reacts with cholera toxin (CT) antibody on immunoblots. Here, we have extended this observation to other species of Campylobacter, including C. coli, C. lari, C. fetus, C. hyointestinalis, and C. upsaliensis, the common 53-kDa OMP of which reacted with CT antibody in immunoblotting assays. There were additional reactive bands for C. fetus. As with C. jejuni, this finding may lead to the erroneous conclusion that these additional species produce a functional CTLT. However, this common cross-reactive OMP can be explored as a vaccine candidate to prevent campylobacteriosis.

* Corresponding author. Mailing address: Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait. Phone and fax: (965) 533-2719. E-mail: john{at}hsc.edu.kw

{triangledown} Published ahead of print on 19 March 2008.

Clinical and Vaccine Immunology, May 2008, p. 859-862, Vol. 15, No. 5
1071-412X/08/$08.00+0     doi:10.1128/CVI.00471-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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