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Clinical and Vaccine Immunology, April 2008, p. 720-725, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00224-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Porcine Reproductive and Respiratory Syndrome Virus Infects Mature Porcine Dendritic Cells and Up-Regulates Interleukin-10 Production{triangledown}

Lilian Flores-Mendoza,1 Erika Silva-Campa,1 Mónica Reséndiz,1 Fernando A. Osorio,2 and Jesús Hernández1*

Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora 83000, Mexico,1 Department of Veterinary and Biomedical Sciences, University of Nebraska—Lincoln, Lincoln, Nebraska 68583-09052

Received 1 June 2007/ Returned for modification 8 September 2007/ Accepted 1 February 2008

Porcine reproductive and respiratory syndrome virus (PRRSV) infects mature dendritic cells (mDCs) derived from porcine monocytes and matured with lipopolysaccharide. The infection of mDCs induced apoptosis, reduced the expression of CD80/86 and major histocompatibility complex class II molecules, and increased the expression of interleukin-10, thus suggesting that such mDC modulation results in the impairment of T-cell activation.

* Corresponding author. Mailing address: P.O. Box 1735, Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C. Carretera a la Victoria, Km. 0.6., Hermosillo, Sonora, México. Phone: 52 662 289 2400. Fax: 52 662 2800094. E-mail: jhdez{at}ciad.mx

{triangledown} Published ahead of print on 13 February 2008.

Clinical and Vaccine Immunology, April 2008, p. 720-725, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00224-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Genini, S., Delputte, P. L., Malinverni, R., Cecere, M., Stella, A., Nauwynck, H. J., Giuffra, E. (2008). Genome-wide transcriptional response of primary alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 89: 2550-2564 [Abstract] [Full Text]  


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