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Clinical and Vaccine Immunology, April 2008, p. 707-712, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00005-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Canine Distemper Virus Strains Circulating among North American Dogs{triangledown}

Sanjay Kapil,1,2* Robin W. Allison,2 Larry Johnston III,1 Brandy L. Murray,1 Steven Holland,1 Jim Meinkoth,2 and Bill Johnson1,2

Oklahoma Animal Disease Diagnostic Laboratory (OADDL), Stillwater, Oklahoma 74078,1 Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Stillwater, Oklahoma 740782

Received 5 January 2008/ Returned for modification 22 January 2008/ Accepted 24 January 2008

Canine distemper virus (CDV) is a highly contagious virus that causes multisystemic disease in dogs. We received seven samples from dogs with CD from the United States during 2007. CDV isolates from these samples formed large, multinucleated syncytia in a Vero cell line expressing canine signaling lymphocyte activation molecule (SLAM). Based on the hemagglutinin gene sequences, the CDV isolates from three states (California, Missouri, and Oklahoma) formed two CDV genetic groups: group I (major; six of seven isolates) consisted of CDV isolates closely related to the European wildlife lineage of CDV, and group II (minor; one of seven isolates) was genetically related to the Arctic-like lineage of CDV. However, both CDV groups were genetically different from the current vaccine strains that belong to the American-1 lineage of the old (1930 to 1950) CDV isolates.

* Corresponding author. Mailing address: Oklahoma Animal Disease Diagnostic Laboratory, Center for Veterinary Health Sciences, Farm and Ridge Road, Stillwater, OK 74078. Phone: (405) 744-6623. Fax: (405) 744-8612. E-mail: sanjay.kapil{at}okstate.edu

{triangledown} Published ahead of print on 6 February 2008.

Clinical and Vaccine Immunology, April 2008, p. 707-712, Vol. 15, No. 4
1071-412X/08/$08.00+0     doi:10.1128/CVI.00005-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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