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Clinical and Vaccine Immunology, February 2008, p. 382-384, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00437-06
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Use of Commercial Enzyme Immunoassays To Detect Antibodies to the Herpes Simplex Virus Type 2 Glycoprotein G in a Low-Risk Population in Hanoi, Vietnam{triangledown}

Thoai D. Ngo,1 Oliver Laeyendecker,1,2 Hanh La,3 Wayne Hogrefe,4 Rhoda Ashley Morrow,5 and Thomas C. Quinn1,2*

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland,1 Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland,2 Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland,3 Focus Technologies, Cypress, California,4 Department of Laboratory of Medicine, University of Washington, Seattle, Washington5

Received 15 November 2006/ Returned for modification 16 April 2007/ Accepted 29 November 2007

Sera from 1,238 Vietnamese women in Hanoi were tested for herpes simplex virus type 2 (HSV-2). HSV-2 prevalence was 2.0%. The Kalon and Biokit assays showed significantly higher concordance to Western blotting data than did the Focus assay (P < 0.01). Screening by Focus and then retesting with Kalon/Biokit of positive samples can reduce falsely positive results significantly (P < 0.01).

* Corresponding author. Mailing address: Department of Infectious Diseases, Johns Hopkins University School of Medicine, 1721 East Madison Street, Ross Building, Room 1159, Baltimore, MD 21205. Phone: (410) 955-3151. Fax: (410) 614-9775. E-mail: tquinn{at}jhmi.edu

{triangledown} Published ahead of print on 12 December 2007.

Clinical and Vaccine Immunology, February 2008, p. 382-384, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00437-06
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Smith, J S, Bailey, R C, Westreich, D J, Maclean, I, Agot, K, Ndinya-Achola, J O, Hogrefe, W, Morrow, R A, Moses, S (2009). Herpes simplex virus type 2 antibody detection performance in Kisumu, Kenya, using the Herpeselect ELISA, Kalon ELISA, Western blot and inhibition testing. Sex. Transm. Infect. 85: 92-96 [Abstract] [Full Text]  
  • Ngo, T. D., Laeyendecker, O., Morrow, R. A., Lai, S., Quinn, T. C. (2008). Comparison of Three Commercial Immunoassays for Detection of Herpes Simplex Virus Type 2 Antibodies in Commercial Sex Workers in Yunnan Province, China. CVI 15: 1301-1303 [Abstract] [Full Text]  


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