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 Previous Article

Clinical and Vaccine Immunology, December 2008, p. 1888-1890, Vol. 15, No. 12
1071-412X/08/$08.00+0     doi:10.1128/CVI.00209-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Influence of Interleukin 1{alpha} (IL-1{alpha}), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis{triangledown}

Aspasia Tsezou,1,2,3* Lazaros Poultsides,4 Fotini Kostopoulou,1 Elias Zintzaras,5 Maria Satra,3 Sofia Kitsiou-Tzeli,6 and Konstantinos N. Malizos2,4

University of Thessalia, Medical School, Laboratory of Cytogenetics and Molecular Genetics, Larissa, Greece,1 Institute of Biomedical Research and Technology, Larissa, Greece,2 University of Thessalia, Medical School, Department of Biology, Larissa, Greece,3 University of Thessalia, Medical School, Department of Orthopaedics, Larissa, Greece,4 University of Thessalia, Medical School, Department of Bioinformatics, Larissa, Greece,5 University of Athens, Department of Medical Genetics, Athens, Greece6

Received 29 May 2008/ Returned for modification 2 July 2008/ Accepted 6 October 2008

The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1{alpha} (IL-1{alpha}) –889-C/T, IL-4 –1098-G/T and –590-C/T, and IL-6 –174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.

* Corresponding author. Mailing address: University of Thessalia, Medical School, Department of Biology, Mezourlo 41 222 Larissa, Greece. Phone: 30-2410-682557. Fax: 302291025758. E-mail: atsezou{at}med.uth.gr

{triangledown} Published ahead of print on 29 October 2008.

Clinical and Vaccine Immunology, December 2008, p. 1888-1890, Vol. 15, No. 12
1071-412X/08/$08.00+0     doi:10.1128/CVI.00209-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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