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Clinical and Vaccine Immunology, October 2008, p. 1623-1624, Vol. 15, No. 10
1071-412X/08/$08.00+0     doi:10.1128/CVI.00176-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

CD4 Stabilization Tubes Provide Improved Accuracy of Absolute CD4 T-Cell Counts Compared to Standard K3 EDTA Tubes in Human Immunodeficiency Virus Immunologic Monitoring in Resource-Poor Settings{triangledown}

Joseph P. Shott,1,2* Boaz Iga,3 Fredrick Makumbi,3,5 Charles Luswata,3 Charles Kagulire,3 Josephine Nammanda,3 Lisa A. Mills,3,4 David Serwadda,5 Thomas C. Quinn,2,4 and Steven J. Reynolds2,4

Clinical Monitoring Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702,1 National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland,2 Rakai Health Sciences Program, Kalisizo, Rakai District, Uganda,3 Johns Hopkins Medical Institutions, Baltimore, Maryland,4 School of Public Health, Makerere University, Kampala, Uganda5

Received 19 May 2008/ Returned for modification 18 June 2008/ Accepted 15 August 2008

CD4 stabilization tubes have the ability to ensure internal quality control in the human immunodeficiency virus (HIV) monitoring laboratory by maintaining accurate absolute CD4 T-cell counts for up to 6 days. Here, we assessed this technology for its use in an HIV clinical monitoring laboratory in a resource-poor setting in rural Uganda.

* Corresponding author. Mailing address: SAIC-Frederick, Inc., NIAID/NIH—Uganda, Rakai Health Sciences Program, P.O. Box 279, Kalisizo, Rakai District, Uganda. Phone: 256 774 884 005. Fax: 256 382 400 013. E-mail: ShottJ{at}mail.nih.gov

{triangledown} Published ahead of print on 27 August 2008.

Clinical and Vaccine Immunology, October 2008, p. 1623-1624, Vol. 15, No. 10
1071-412X/08/$08.00+0     doi:10.1128/CVI.00176-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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