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 Previous Article

Clinical and Vaccine Immunology, September 2007, p. 1245-1248, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00217-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evaluation of Four Whole-Cell Leptospira-Based Serological Tests for Diagnosis of Urban Leptospirosis{triangledown}

Alan J. A. McBride,1 Balbino L. Santos,1 Adriano Queiroz,1 Andréia C. Santos,1 Rudy A. Hartskeerl,2 Mitermayer G. Reis,1 and Albert I. Ko1,3*

Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil,1 Department of Biomedical Research, Royal Tropical Institute (KIT), Amsterdam, The Netherlands,2 Division of International Medicine and Infectious Disease, Weill Medical College of Cornell University, New York, New York3

Received 4 May 2007/ Returned for modification 10 July 2007/ Accepted 17 July 2007

Four serologic assays for leptospirosis had sensitivities of 72 to 88% and specificities of 88 to 100% in the setting of highly endemic urban transmission, indicating that assays using enzyme-linked immunosorbency and rapid formats may be used as alternatives to the microscopic agglutination test for diagnosing urban leptospirosis. Testing a second sample will be required in cases with an initial negative result, since sensitivity was low (46 to 68%) during the first week of illness.

* Corresponding author. Mailing address: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Salvador 40295-001, Bahia, Brazil. Phone: 55 71 3176 2302. Fax: 55 71 3176 2281. E-mail: aik2001{at}med.cornell.edu

{triangledown} Published ahead of print on 25 July 2007.

Clinical and Vaccine Immunology, September 2007, p. 1245-1248, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00217-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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