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Clinical and Vaccine Immunology, September 2007, p. 1239-1241, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00185-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Follow-Up Study of Tuberculosis-Exposed Supermarket Customers with Negative Tuberculin Skin Test Results in Association with Positive Gamma Interferon Release Assay Results{triangledown}

Willeke P. J. Franken,1* Ben F. P. J. Koster,2 Ailko W. J. Bossink,4 Steven F. T. Thijsen,3 John J. M. Bouwman,3 Jaap T. van Dissel,1 and Sandra M. Arend1

Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands,1 Department of Tuberculosis Control, Municipal Health Authority, Utrecht, The Netherlands,2 Department of Medical Microbiology and Immunology, Diakonessenhuis, Utrecht/Zeist, The Netherlands,3 Department of Pulmonology, Heart Lung Center Utrecht, Diakonessenhuis, Utrecht, The Netherlands4

Received 17 April 2007/ Returned for modification 21 May 2007/ Accepted 29 June 2007

We report a follow-up study of 29 subjects with negative tuberculin skin test (TST) results in association with positive gamma interferon release assay (IGRA) results, mainly due to responses to CFP-10 in the T-SPOT.TB assay, during a contact investigation. One year later, 12/29 subjects (41%) had converted to positive TST results in association with negative IGRA results.

* Corresponding author. Mailing address: Department of Infectious Diseases, C5-P 37, Leiden University Medical Center, P. O. Box 9600, 2300 RC Leiden, The Netherlands. Phone: 31-71-526-3582. Fax: 31-71-526-6758. E-mail: w.p.j.franken{at}lumc.nl

{triangledown} Published ahead of print on 11 July 2007.

Clinical and Vaccine Immunology, September 2007, p. 1239-1241, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00185-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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