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Clinical and Vaccine Immunology, September 2007, p. 1235-1238, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00137-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Yersinia pestis CO92{Delta}yopH Is a Potent Live, Attenuated Plague Vaccine{triangledown}

Sarah S. Bubeck and Peter H. Dube*

Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, Texas 78229

Received 27 March 2007/ Returned for modification 28 May 2007/ Accepted 11 July 2007

An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92{Delta}yopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr., San Antonio, TX 78229. Phone: (210) 567-0657. Fax: (210) 567-6612. E-mail: dube{at}uthscsa.edu

{triangledown} Published ahead of print on 25 July 2007.

Clinical and Vaccine Immunology, September 2007, p. 1235-1238, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00137-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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