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Clinical and Vaccine Immunology, September 2007, p. 1231-1234, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00057-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Anti-16-Kilodalton Mycobacterial Protein Immunoglobulin M Levels in Healthy but Purified Protein Derivative-Reactive Children Decrease after Chemoprophylaxis{triangledown}

Guido Sireci,1* Francesco Dieli,1 Diana Di Liberto,1 Simona Buccheri,1 Marco Pio La Manna,1 Francesco Scarpa,1 Pasquale Macaluso,1 Amelia Romano,2 Lucina Titone,2 Paola Di Carlo,2 Mahavir Singh,3 Jurayi Ivanyi,4 and Alfredo Salerno1

Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211,1 Istituto di Patologia Infettiva e Virologia, Università di Palermo, Piazza Montalto 8, Palermo, Italy,2 Lionex Diagnostics and Therapeutics GmbH, Mascheroder Weg 1b, D-38124 Braunschweig, Germany,3 Department of Oral Medicine and Pathology, KCL Medical and Dental School at Guy's Hospital, London, United Kingdom4

Received 30 January 2007/ Returned for modification 27 February 2007/ Accepted 29 June 2007

Serum responses against Mycobacterium tuberculosis HSP16 were determined for children with tuberculosis (TB) and for healthy purified protein derivative (PPD)-positive and PPD-negative children. Immunoglobulin G (IgG) and IgM responses were higher for TB patients than for other groups. After chemotherapy, IgM and IgG responses decreased for TB patients and PPD-positive subjects. Monitoring of anti-M. tuberculosis HSP16 responses could assist in the management of pediatric TB.

* Corresponding author. Mailing address: Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italy. Phone: 39 091 6555939. Fax: 39 091 6555924. E-mail: sireci{at}unipa.it

{triangledown} Published ahead of print on 11 July 2007.

Clinical and Vaccine Immunology, September 2007, p. 1231-1234, Vol. 14, No. 9
1071-412X/07/$08.00+0     doi:10.1128/CVI.00057-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Anderson, B. L., Welch, R. J., Litwin, C. M. (2008). Assessment of Three Commercially Available Serologic Assays for Detection of Antibodies to Mycobacterium tuberculosis and Identification of Active Tuberculosis. CVI 15: 1644-1649 [Abstract] [Full Text]  


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