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Clinical and Vaccine Immunology, August 2007, p. 1005-1012, Vol. 14, No. 8
1071-412X/07/$08.00+0     doi:10.1128/CVI.00087-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Parasite-Induced Chronic Inflammation Is Not Exacerbated by Immunotherapy before or during Trypanosoma cruzi Infection{triangledown}

Malcolm S. Duthie, Maria Kahn, Arsen Zakayan, Maria White, and Stuart J. Kahn*

Infectious Disease Research Institute, 1124 Columbia St., Suite 400, Seattle, Washington 98104

Received 17 February 2007/ Returned for modification 9 May 2007/ Accepted 23 May 2007

Trypanosoma cruzi infection causes Chagas' disease, a chronic inflammatory disease. The specific inflammatory responses that cause Chagas' disease remain unclear, but data argue that parasites that persist in the host stimulate chronic self-damaging immune responses. Because T. cruzi appears to stimulate self-damaging responses, the enthusiasm to develop vaccines that boost antiparasite responses that might increase self-damaging responses has been limited. We previously demonstrated that immunization with a T. cruzi trans-sialidase protein or adoptive transfer of trans-sialidase-specific T-cell clones decreased parasitemia, morbidity, and mortality. Here we report that immunization or adoptive transfer with the protein or clones, before or during T. cruzi infection, boosts the anti-T. cruzi immune response without exacerbating acute or chronic tissue inflammation. These results argue that prophylactic and therapeutic immunotherapy for Chagas' disease can be developed safely.

* Corresponding author. Mailing address: IDRI, 1124 Columbia St., Suite 400, Seattle, WA 98104. Phone: (206) 330-2509. Fax: (206) 381-3678. E-mail: skahn{at}idri.org

{triangledown} Published ahead of print on 30 May 2007.

Clinical and Vaccine Immunology, August 2007, p. 1005-1012, Vol. 14, No. 8
1071-412X/07/$08.00+0     doi:10.1128/CVI.00087-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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