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Clinical and Vaccine Immunology, July 2007, p. 926-928, Vol. 14, No. 7
1071-412X/07/$08.00+0     doi:10.1128/CVI.00450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Needle-Free Skin Patch Delivery of a Vaccine for a Potentially Pandemic Influenza Virus Provides Protection against Lethal Challenge in Mice{triangledown}

Sanjay Garg,1,{dagger} Mary Hoelscher,1,{dagger} Jessica A. Belser,1 Chong Wang,1 Lakshmi Jayashankar,1 Zhu Guo,1 Ross H. Durland,2 Jacqueline M. Katz,1 and Suryaprakash Sambhara1*

Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 Altea Therapeutics, Tucker, Georgia 300842

Received 20 November 2006/ Returned for modification 9 March 2007/ Accepted 30 April 2007

In the event of another influenza virus pandemic, strategies for effective mass vaccination will urgently be needed. We used a novel transdermal patch delivery technology, known as the PassPort system, to vaccinate mice with recombinant H5 hemagglutinin with or without immunomodulators. This needle-free form of vaccine delivery induced robust serum antibody responses that were augmented by different immunomodulators that stimulated the innate immune system and protected mice against lethal challenge with a highly pathogenic avian H5N1 influenza virus.

* Corresponding author. Mailing address: Influenza Division, Mail-Stop G-16, CCID, Centers for Disease Control and Prevention, 1600 Clifton Rd., Atlanta, GA 30333. Phone: (404) 639-3800. Fax: (404) 639-2334. E-mail: ssambhara{at}cdc.gov

{triangledown} Published ahead of print on 9 May 2007.

{dagger} S.G. and M.H. contributed equally to the present study.

Clinical and Vaccine Immunology, July 2007, p. 926-928, Vol. 14, No. 7
1071-412X/07/$08.00+0     doi:10.1128/CVI.00450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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