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Clinical and Vaccine Immunology, June 2007, p. 804-807, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00098-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Age-Specific Salivary Immunoglobulin A Response to Streptococcus mutans GbpB{triangledown}

Ruchele D. Nogueira,1 Alessandra C. Alves,1 William F. King,2 Reginaldo B. Gonçalves,1 José F. Höfling,1 Daniel J. Smith,2 and Renata O. Mattos-Graner1*

Department of Oral Diagnosis, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil,1 Department of Immunology, The Forsyth Institute, Boston, Massachusetts2

Received 27 February 2007/ Returned for modification 29 March 2007/ Accepted 20 April 2007

In a follow-up study of children infected with Streptococcus mutans at an early age (children previously shown to respond poorly to S. mutans GbpB), there was a delay in their immune response, rather than a complete inability to respond to this antigen. Epitopes in the N-terminal third of GbpB were identified as targets for naturally induced immunoglobulin A antibody in children at an early age.

* Corresponding author. Mailing address: Faculdade de Odontologia de Piracicaba-UNICAMP, Área de Microbiologia e Imunologia, Av. Limeira, 901, CEP 13414-903 Piracicaba, São Paulo, Brazil. Phone: 55 19 2106 5707. Fax: 55 19 2106 5218. E-mail: rmgraner{at}fop.unicamp.br

{triangledown} Published ahead of print on 2 May 2007.

Clinical and Vaccine Immunology, June 2007, p. 804-807, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00098-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Alves, A. C., Nogueira, R. D., Stipp, R. N., Pampolini, F., Moraes, A. B. A., Goncalves, R. B., Hofling, J. F., Li, Y., Mattos-Graner, R. O. (2009). Prospective study of potential sources of Streptococcus mutans transmission in nursery school children. J Med Microbiol 58: 476-481 [Abstract] [Full Text]  
  • Nogueira, R. D., King, W. F., Gunda, G., Culshaw, S., Taubman, M. A., Mattos-Graner, R. O., Smith, D. J. (2008). Mutans Streptococcal Infection Induces Salivary Antibody to Virulence Proteins and Associated Functional Domains. Infect. Immun. 76: 3606-3613 [Abstract] [Full Text]  


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