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Clinical and Vaccine Immunology, June 2007, p. 792-795, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00478-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Noninferiority of Antibody Response to Human Papillomavirus Type 16 in Subjects Vaccinated with Monovalent and Quadrivalent L1 Virus-Like Particle Vaccines{triangledown}

Suzanne M. Garland,1 Marc Steben,2* Mauricio Hernandez-Avila,3 Laura A. Koutsky,4 Cosette M. Wheeler,5 Gonzalo Perez,6 Diane M. Harper,7 Sepp Leodolter,8 Grace W. K. Tang,9 Daron G. Ferris,10 Mark T. Esser,11 Scott C. Vuocolo,11 Micki Nelson,11 Radha Railkar,11 Carlos Sattler,11 Eliav Barr,11,{dagger} on behalf of the 012 Study Investigators

Microbiology and Infectious Diseases Department, Royal Women's Hospital, Carlton, and Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia,1 Direction Risques Biologiques, Environnementaux et Occupationnels, Institut National de Santé Publique du Québec, Montréal, Québec, Canada,2 National Institute of Public Health, Cuernavaca, Morelos, Mexico,3 Department of Epidemiology, University of Washington, Seattle, Washington,4 Departments of Molecular Genetics and Microbiology and of Obstetrics and Gynecology, University of New Mexico, Albuquerque, New Mexico,5 National Research Center, Group Saludcoop, Bogotá, Colombia,6 Norris Cotton Cancer Center and Departments of Obstetrics and Gynecology and of Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire,7 Department of Gynecology and Obstetrics, Women's Health Clinic, Medical University of Vienna, Vienna, Austria,8 Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong, People's Republic of China,9 Departments of Family Medicine and of Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia,10 Merck Research Laboratories, West Point, Pennsylvania,11

Received 19 December 2006/ Returned for modification 27 February 2007/ Accepted 2 April 2007

The incorporation of multiple antigens into a single human papillomavirus (HPV) vaccine may induce immune interference. To evaluate whether interference occurs when HPV type 16 (HPV16) virus-like particles are combined in a multivalent vaccine, we conducted a study to evaluate anti-HPV16 responses among subjects receiving three-dose regimens of either a monovalent HPV16 vaccine or a quadrivalent HPV (types 6, 11, 16, and 18) vaccine.

* Corresponding author. Mailing address: Direction Risques Biologiques, Environnementaux et Occupationnels, Institut National de Santé Publique du Québec, 190 Boulevard Crémazie Est, Montréal, Québec, Canada H2P 1E2. Phone: (514) 864-1600, ext. 3234. Fax: (514) 864-7646. E-mail: marc.steben{at}inspq.qc.ca

{triangledown} Published ahead of print on 11 April 2007.

{dagger} A listing of investigators can be found in the acknowledgments.

Clinical and Vaccine Immunology, June 2007, p. 792-795, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00478-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Garland, S. M., Insinga, R. P., Sings, H. L., Haupt, R. M., Joura, E. A. (2009). Human Papillomavirus Infections and Vulvar Disease Development. Cancer Epidemiol. Biomarkers Prev. 18: 1777-1784 [Abstract] [Full Text]  
  • LoBue, A. D., Thompson, J. M., Lindesmith, L., Johnston, R. E., Baric, R. S. (2009). Alphavirus-Adjuvanted Norovirus-Like Particle Vaccines: Heterologous, Humoral, and Mucosal Immune Responses Protect against Murine Norovirus Challenge. J. Virol. 83: 3212-3227 [Abstract] [Full Text]  


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