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Clinical and Vaccine Immunology, May 2007, p. 635-637, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00431-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Borreliacidal OspC Antibody Response of Canines with Lyme Disease Differs Significantly from That of Humans with Lyme Disease{triangledown}

Steven D. Lovrich,1 Rhonda L. La Fleur,3 Dean A. Jobe,1 Jennifer C. Johnson,3 Krista E. Asp,1 Ronald F. Schell,4 and Steven M. Callister1,2*

Microbiology Research Laboratory,1 Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin 54601,2 Schering Plough Animal Health Corporation, Elkhorn, Nebraska 68022,3 Wisconsin State Laboratory of Hygiene, Madison, Wisconsin 537064

Received 16 November 2006/ Returned for modification 6 February 2007/ Accepted 22 February 2007

Humans reliably produce high concentrations of borreliacidal OspC antibodies specific for the seven C-terminal amino acids shortly after infection with Borrelia burgdorferi. We show that dogs also produce OspC borreliacidal antibodies but that their frequencies, intensities, and antigenicities differ significantly. The findings therefore confirm a major difference between the borreliacidal antibody responses of humans and canines with Lyme disease.

* Corresponding author. Mailing address: Microbiology Research Laboratory, Gundersen Lutheran Medical Center, 1300 Badger Street, La Crosse, Wisconsin 54601. Phone: (608) 775-2042. Fax: (608) 775-6602. E-mail: SMCallis{at}gundluth.org

{triangledown} Published ahead of print on 7 March 2007.

Clinical and Vaccine Immunology, May 2007, p. 635-637, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00431-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • LaFleur, R. L., Dant, J. C., Wasmoen, T. L., Callister, S. M., Jobe, D. A., Lovrich, S. D., Warner, T. F., Abdelmagid, O., Schell, R. F. (2009). Bacterin That Induces Anti-OspA and Anti-OspC Borreliacidal Antibodies Provides a High Level of Protection against Canine Lyme Disease. CVI 16: 253-259 [Abstract] [Full Text]  


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