This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Earnhart, C. G.
Right arrow Articles by Marconi, R. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Earnhart, C. G.
Right arrow Articles by Marconi, R. T.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, May 2007, p. 628-634, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00409-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

OspC Phylogenetic Analyses Support the Feasibility of a Broadly Protective Polyvalent Chimeric Lyme Disease Vaccine{triangledown}

Christopher G. Earnhart1 and Richard T. Marconi1,2*

Department of Microbiology and Immunology,1 Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298-06782

Received 1 November 2006/ Returned for modification 18 January 2007/ Accepted 5 March 2007

Using available Borrelia outer surface protein C (OspC) sequences, a phylogenetic analysis was undertaken to delineate the number of antigenic domains required for inclusion in a broadly protective, chimeric, OspC-based Lyme disease vaccine. The data indicate that approximately 34 would be required and that an OspC-based vaccinogen is feasible.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, Richmond, VA 23298-0678. Phone: (804) 828-3888. Fax: (804) 827-1548. E-mail: rmarconi{at}vcu.edu

{triangledown} Published ahead of print on 14 March 2007.

Clinical and Vaccine Immunology, May 2007, p. 628-634, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00409-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vojdani, A., Hebroni, F., Raphael, Y., Erde, J., Raxlen, B. (2009). Novel Diagnosis of Lyme Disease: Potential for CAM Intervention. Evid Based Complement Alternat Med 6: 283-295 [Abstract] [Full Text]  
  • Nardelli, D. T., Callister, S. M., Schell, R. F. (2008). Lyme Arthritis: Current Concepts and a Change in Paradigm. CVI 15: 21-34 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»