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Clinical and Vaccine Immunology, March 2007, p. 256-261, Vol. 14, No. 3
1071-412X/07/$08.00+0     doi:10.1128/CVI.00400-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Association between Mannose-Binding Lectin Deficiency and Septic Shock following Acute Pyelonephritis Due to Escherichia coli{triangledown}

Alex Smithson,1* Ana Muñoz,1 Belen Suarez,2 Sara Maria Soto,3 Rafael Perello,1 Alex Soriano,1 Jose Antonio Martinez,1 Jordi Vila,3 Juan Pablo Horcajada,1 Jose Mensa,1 and Francisco Lozano2

Infectious Diseases Unit,1 Department of Immunology,2 Department of Microbiology, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain3

Received 27 October 2006/ Returned for modification 5 December 2006/ Accepted 18 December 2006

Structural and promoter MBL2 gene polymorphisms responsible for low MBL levels are associated with increased risk of infection. The objective of this study was to assess the possible association between polymorphisms of the MBL2 gene and the incidence of septic shock and bacteremia in patients with acute pyelonephritis due to Escherichia coli. The study included 62 female patients with acute pyelonephritis due to E. coli who required hospital admission, as well as 133 healthy control subjects. Six single-nucleotide polymorphisms (–550 G/C, –221 C/G, +4 C/T, codon 52 CGT/TGT, codon 54 GGC/GAC, and codon 57 GGA/GAA) in the MBL2 gene were genotyped by using a sequence-based typing technique. No significant differences were observed in the frequencies for low-expression MBL2 genotypes (O/O and LXA/O) between patients with acute pyelonephritis and healthy controls. Patients with acute pyelonephritis and septic shock had a higher incidence of low-expression MBL2 genotypes than patients with acute pyelonephritis without septic shock (odds ratio = 9.019, 95% confidence interval = 1.23 to 65.93; P = 0.03). No association was found between bacteremic acute pyelonephritis and low-expression MBL2 genotypes. We found that low-expression MBL2 genotypes predispose to septic shock but not to bacteremia in patients with E. coli-induced acute pyelonephritis. Determination of MBL2 polymorphisms could be useful for assessing the risk of septic shock in women undergoing acute pyelonephritis.

* Corresponding author. Mailing address: Infectious Diseases Unit, Hospital Clínic, IDIBAPS, Edificio Helios, 1 Planta C/Villarroel 170, 08036 Barcelona, Spain. Phone: 34-93 227 54 00. Fax: 34-93 227 93 22. E-mail: asa30412{at}hotmail.com.

{triangledown} Published ahead of print on 3 January 2007.

Clinical and Vaccine Immunology, March 2007, p. 256-261, Vol. 14, No. 3
1071-412X/07/$08.00+0     doi:10.1128/CVI.00400-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Hellemann, D., Larsson, A., Madsen, H. O., Bonde, J., Jarlov, J. O., Wiis, J., Faber, T., Wetterslev, J., Garred, P. (2007). Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients. Hum Mol Genet 16: 3071-3080 [Abstract] [Full Text]  


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