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Clinical and Vaccine Immunology, November 2007, p. 1442-1450, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00264-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Age-Stratified Prevalences of Pneumococcal-Serotype-Specific Immunoglobulin G in England and Their Relationship to the Serotype-Specific Incidence of Invasive Pneumococcal Disease Prior to the Introduction of the Pneumococcal 7-Valent Conjugate Vaccine{triangledown}

Paul Balmer,1 Ray Borrow,1* Jamie Findlow,1 Rosalind Warrington,1 Sarah Frankland,1 Pauline Waight,2 Robert George,3 Nick Andrews,4 and Elizabeth Miller2

Vaccine Evaluation Unit, Health Protection Agency North West, Manchester Royal Infirmary, Manchester, United Kingdom,1 Immunisation Division, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom,2 Respiratory and Systemic Infections Laboratory, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom,3 Statistics Unit, Centre for Infections, Health Protection Agency, Colindale, London, United Kingdom4

Received 28 June 2007/ Returned for modification 15 August 2007/ Accepted 9 September 2007

Recent changes to the childhood immunization schedule in the United Kingdom have resulted in the inclusion of the 7-valent pneumococcal conjugate vaccine. However, the seroprevalence of pneumococcal antibodies in the population was unknown. To address this, we measured pneumococcal, age-specific immunoglobulin G (IgG) concentrations specific for nine serotypes by an assay run on the Bioplex platform, using 2,664 serum samples collected in England from 2000 to 2004. The lowest concentrations of IgG specific to all serotypes and the proportions of serotype-specific IgG concentrations of ≥0.35 µg/ml were observed in children aged <1 year. From 1 year on, there was a general increase in antibody levels with increasing age, and they remained high in adults. Maternal antibody was detected in young children aged <36 days but waned rapidly. Comparison of the age-specific seroprevalence of serotype-specific IgG to the serotype-specific incidence of invasive pneumococcal disease demonstrated a general inverse relationship for all age groups except the elderly. These data provide a baseline for natural immunity to the pneumococcal serotypes analyzed prior to the introduction of pneumococcal conjugate vaccine in the United Kingdom.

* Corresponding author. Mailing address: Vaccine Evaluation Unit, Health Protection Agency, Manchester Laboratory, Clinical Sciences Building 2, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom M13 9WZ. Phone: 44 161 276 6793. Fax: 44 161 276 6972. E-mail: ray.borrow{at}hpa.org.uk

{triangledown} Published ahead of print on 19 September 2007.

Clinical and Vaccine Immunology, November 2007, p. 1442-1450, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00264-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Simell, B., Lahdenkari, M., Reunanen, A., Kayhty, H., Vakevainen, M. (2008). Effects of Ageing and Gender on Naturally Acquired Antibodies to Pneumococcal Capsular Polysaccharides and Virulence-Associated Proteins. CVI 15: 1391-1397 [Abstract] [Full Text]  


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