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Clinical and Vaccine Immunology, November 2007, p. 1416-1419, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00312-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Development of a Rapid and Convenient Method for Determination of Rubella Virus-Specific Immunoglobulin G Avidity{triangledown}

Christelle Vauloup-Fellous,1,2* Jessica Ursulet-Diser,2 and Liliane Grangeot-Keros1,2

Faculty of Medicine Paris-Sud, University Paris-Sud 11, Le Kremlin-Bicêtre F-94276, France,1 Department of Microbiology and Immunology, AP-HP, Antoine Béclère Hospital, Clamart F-92141, France2

Received 24 July 2007/ Returned for modification 6 September 2007/ Accepted 19 September 2007

We describe here a rapid and semiautomated method for the determination of rubella virus immunoglobulin G (IgG) avidity with the VIDAS instrument. A total of 153 serum samples from persons with naturally acquired rubella virus infections (n = 98), from vaccinated persons (n = 44), and from patients with autoantibodies (n = 11) were included in this study. The rubella virus-specific IgG avidity assay we developed for the VIDAS instrument was evaluated by comparison with an in-house method. Results obtained with the VIDAS instrument allow considering this method valuable to help confirm or exclude acute primary infection or recent vaccination.

* Corresponding author. Mailing address: Service de Microbiologie-Immunologie Biologique, Hôpital Antoine Béclère, 92141 Clamart Cedex, France. Phone: (33) 1 45 37 42 86. Fax: (33) 1 46 32 67 96. E-mail: christelle.vauloup{at}abc.aphp.fr

{triangledown} Published ahead of print on 3 October 2007.

Clinical and Vaccine Immunology, November 2007, p. 1416-1419, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00312-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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