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Clinical and Vaccine Immunology, January 2007, p. 94-98, Vol. 14, No. 1
1071-412X/07/$08.00+0     doi:10.1128/CVI.00296-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Binding of Glucuronoxylomannan to the CD14 Receptor in Human A549 Alveolar Cells Induces Interleukin-8 Production{triangledown}

Fabiane M. Barbosa,1 Fernanda L. Fonseca,1 Rodrigo T. Figueiredo,2 Marcelo T. Bozza,2 Arturo Casadevall,3,4 Leonardo Nimrichter,1,{dagger} and Marcio L. Rodrigues1,{dagger}*

Laboratório de Estudos Integrados em Bioquímica Microbiana, Departamento de Microbiologia Geral,1 Departamento de Imunologia, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, 21941590 Rio de Janeiro, Brazil,2 Department of Microbiology and Immunology,3 Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave., Bronx, New York 104614

Received 23 August 2006/ Returned for modification 12 October 2006/ Accepted 27 October 2006

Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans. GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.

* Corresponding author. Mailing address: Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude (CCS), bloco I, 21941590 Rio de Janeiro, Brazil. Phone: 55 21 2562 6740. Fax: 55 21 2560 8344. E-mail: marcio{at}micro.ufrj.br.

{triangledown} Published ahead of print on 8 November 2006.

{dagger} L.N. and M.L.R. share senior authorship on this article.

Clinical and Vaccine Immunology, January 2007, p. 94-98, Vol. 14, No. 1
1071-412X/07/$08.00+0     doi:10.1128/CVI.00296-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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