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Clinical and Vaccine Immunology, January 2007, p. 106-109, Vol. 14, No. 1
1071-412X/07/$08.00+0     doi:10.1128/CVI.00216-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Specificity of the Immune Response to a Modified Group B Meningococcal Polysaccharide Conjugate Vaccine{triangledown}

Samuel Moore,* Esmé K. Farley, Peter C. Fusco, and Francis Michon

BioVeris Corporation, Gaithersburg, Maryland 20877

Received 8 June 2006/ Returned for modification 7 July 2006/ Accepted 22 October 2006

Antibodies to a modified group B meningococcal polysaccharide vaccine were examined for antigenic and functional specificities. Bactericidal determinants were investigated by using immunoaffinity columns and competitive inhibition of bactericidal activity in an in vitro killing assay. We conclude that nearly all of the vaccine-induced bactericidal activity is specific for the native polysaccharide.

* Corresponding author. Mailing address: Department of Vaccine Research, BioVeris Corporation, 16020 Industrial Drive, Gaithersburg, MD 20877. Phone: (301) 869-9800. Fax: (301) 947-5312. E-mail: smoore{at}bioveris.com.

{triangledown} Published ahead of print on 1 November 2006.

Clinical and Vaccine Immunology, January 2007, p. 106-109, Vol. 14, No. 1
1071-412X/07/$08.00+0     doi:10.1128/CVI.00216-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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