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Clinical and Vaccine Immunology, August 2006, p. 969-971, Vol. 13, No. 8
1071-412X/06/$08.00+0     doi:10.1128/CVI.00149-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Use of Immunoglobulin G Avidity To Determine the Course of Disease in Visceral and Post-Kala-Azar Dermal Leishmaniasis Patients

Naresh Singh Redhu, Ayan Dey, Veena Balooni, and Sarman Singh*

Division of Clinical Microbiology, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi 110029, India

Received 21 April 2006/ Returned for modification 22 May 2006/ Accepted 30 May 2006

In the present study, anti-Leishmania immunoglobulin G (IgG) avidity was used to estimate the approximate time of disease manifestation. Significant differences (P < 0.0001) were found between the levels of anti-rKE-16 IgG avidity in leishmaniasis patients with recent and chronic diseases. More than 76% of patients with an illness duration of less than 6 months had avidity of less than 70%, 94% of patients had less than 80% avidity, and all (100%) patients with illness of more than 6 months had avidity values higher than 70%. The study showed that avidity could successfully be used to pinpoint the duration of leishmaniasis.

* Corresponding author. Mailing address: Department of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. Phone: 91 11 26588484. Fax: 91 11 26588641. E-mail: sarman_singh{at}yahoo.com.

Clinical and Vaccine Immunology, August 2006, p. 969-971, Vol. 13, No. 8
1071-412X/06/$08.00+0     doi:10.1128/CVI.00149-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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