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Clinical and Vaccine Immunology, July 2006, p. 810-813, Vol. 13, No. 7
1071-412X/06/$08.00+0     doi:10.1128/CVI.00095-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Factors Associated with Immunoglobulin G Subclass Polarization in Naturally Acquired Antibodies to Plasmodium falciparum Merozoite Surface Proteins: a Cross-Sectional Survey in Brazilian Amazonia

Kézia K. G. Scopel,1 Cor J. F. Fontes,2 Marcelo U. Ferreira,3,4 and Érika M. Braga1*

Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil,1 Departamento de Clínica Médica, Universidade Federal de Mato Grosso, Cuiabá, Brazil,2 Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil,3 Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts4

Received 9 March 2006/ Returned for modification 24 April 2006/ Accepted 9 May 2006

We investigated immunoglobulin G (IgG) subclass antibody responses to Plasmodium falciparum merozoite surface protein 1 (MSP-1) and MSP-2 in 112 malaria-exposed subjects in Brazil. IgG3 polarization was primarily epitope driven, being little affected by cumulative or current exposure to malaria and not affected by a subject's age and Fc{gamma} receptor IIA genotype.

* Corresponding author. Mailing address: Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte (MG), Brazil. Phone: 55 31 34992876. Fax: 55 31 34992970. E-mail: embraga{at}icb.ufmg.br.

Clinical and Vaccine Immunology, July 2006, p. 810-813, Vol. 13, No. 7
1071-412X/06/$08.00+0     doi:10.1128/CVI.00095-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Stanisic, D. I., Richards, J. S., McCallum, F. J., Michon, P., King, C. L., Schoepflin, S., Gilson, P. R., Murphy, V. J., Anders, R. F., Mueller, I., Beeson, J. G. (2009). Immunoglobulin G Subclass-Specific Responses against Plasmodium falciparum Merozoite Antigens Are Associated with Control of Parasitemia and Protection from Symptomatic Illness. Infect. Immun. 77: 1165-1174 [Abstract] [Full Text]  
  • SCOPEL, K. K. G., SILVA-NUNES, M. D., MALAFRONTE, R. S., BRAGA, E. M., FERREIRA, M. U. (2007). VARIANT-SPECIFIC ANTIBODIES TO MEROZOITE SURFACE PROTEIN 2 AND CLINICAL EXPRESSION OF PLASMODIUM FALCIPARUM MALARIA IN RURAL AMAZONIANS. Am J Trop Med Hyg 76: 1084-1091 [Abstract] [Full Text]  


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