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Clinical and Vaccine Immunology, June 2006, p. 605-610, Vol. 13, No. 6
1071-412X/06/$08.00+0     doi:10.1128/CVI.00123-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Priming for Immunologic Memory in Adults by Meningococcal Group C Conjugate Vaccination

David M. Vu,1 Alberdina W. de Boer,2 Lisa Danzig,2 George Santos,2 Bridget Canty,1 Betty M. Flores,1 and Dan M. Granoff1*

Children's Hospital Oakland Research Institute, Oakland, California,1 Chiron Corporation, Emeryville, California2

Received 27 January 2006/ Accepted 4 April 2006

Meningococcal group C polysaccharide-protein conjugate vaccines (MCV) prime infants and children for memory anticapsular responses upon subsequent exposure to unconjugated polysaccharide. The objective of this study was to determine whether MCV primes vaccine-naïve adults and adults previously vaccinated with meningococcal polysaccharide vaccine (MPSV) for memory antibody responses. Meningococcal vaccine-naïve adults were randomized to receive either MCV (MCV/naïve group) (n = 35) or pneumococcal conjugate vaccine (PCV) (PCV/naïve group) (n = 34). Participants with a history of receiving MPSV were given MCV (MCV/MPSV group) (n = 26). All subjects were challenged 10 months later with one-fifth of the usual dose of MPSV (10 µg of each polysaccharide). Sera were obtained before the conjugate vaccination and before and 7 days after the MPSV challenge and assayed for immunoglobulin G (IgG) anticapsular antibody concentrations and bactericidal titers. The MCV/naïve group had 7- to 10-fold-higher serum IgG and bactericidal responses after the MPSV challenge than the PCV/naïve group (P < 0.001). The increases (n-fold) in anticapsular antibody concentrations in the MCV/naïve group were greatest in subjects with antibody concentrations of ≤2 µg/ml before the challenge (geometric mean increase [n-fold] of 8.3 versus 1.1 in subjects with concentrations of >2 µg/ml before the challenge; P < 0.0001). Only 3 of 11 MCV-vaccinated subjects who had received MPSV before enrollment and who had antibody concentrations of ≤2 µg/ml before the polysaccharide challenge showed more-than-twofold increases in anticapsular antibody concentration or bactericidal titer after the challenge. MCV vaccination of meningococcal vaccine-naïve adults primes for robust memory antibody responses. There was no evidence of induction of memory by MCV in adults previously vaccinated with MPSV.

* Corresponding author. Mailing address: 5700 Martin Luther King Jr. Way, Oakland, CA 94609. Phone: (510) 450-7640. Fax: (510) 450-7915. E-mail: dgranoff{at}chori.org.

Clinical and Vaccine Immunology, June 2006, p. 605-610, Vol. 13, No. 6
1071-412X/06/$08.00+0     doi:10.1128/CVI.00123-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Granoff, D. M., Welsch, J. A., Ram, S. (2009). Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera. Infect. Immun. 77: 764-769 [Abstract] [Full Text]  
  • Edwards, K. M., Burns, V. E., Adkins, A. E., Carroll, D., Drayson, M., Ring, C. (2008). Meningococcal A Vaccination Response is Enhanced by Acute Stress in Men. Psychosom. Med. 70: 147-151 [Abstract] [Full Text]  
  • Welsch, J. A., Granoff, D. (2007). Immunity to Neisseria meningitidis Group B in Adults despite Lack of Serum Bactericidal Antibody. CVI 14: 1596-1602 [Abstract] [Full Text]  


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