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Clinical and Vaccine Immunology, May 2006, p. 547-552, Vol. 13, No. 5
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.5.547-552.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Peripheral Blood Mononuclear Cells from Individuals Infected with Human T-Cell Lymphotropic Virus Type 1 Have a Reduced Capacity To Respond to Recall Antigens

Rita Elizabeth Mascarenhas,1,4 Cláudia Brodskyn,2 Geisa Barbosa,1,4 Jorge Clarêncio,2 Antônio Souza Andrade-Filho,3,4 Frederico Figueiroa,3,4 Bernardo Galvão-Castro,1,4 and Fernanda Grassi1,4*

Advanced Laboratory of Public Health/Gonçalo Moniz Research Center (CPqGM), Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil,1 Microbiology and Immunoregulation of Integrate Laboratory/Gonçalo Moniz Research Center (CPqGM), Oswaldo Cruz Foundation (FIOCRUZ), Salvador, Bahia, Brazil,2 Neurology and Neurosurgery Foundation, Salvador, Bahia, Brazil,3 Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil4

Received 12 July 2005/ Returned for modification 11 August 2005/ Accepted 16 March 2006

Evidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1) infection leads to chronic immunosuppression and a greater susceptibility to infectious diseases. Spontaneous in vitro proliferation of peripheral blood mononuclear cells (PBMC) is an important immunological feature of HTLV-1-infected individuals. However, the association between spontaneous proliferation and immunosuppression is not clear. In this study, we evaluated the cellular immune responses of PBMC from 58 asymptomatic HTLV-1-infected individuals with PBMC showing or not showing spontaneous proliferation. Individuals with PBMC that spontaneously proliferated had increased proportions of CD4 T cells expressing CD45RO and dramatically reduced responses to recall antigens. In addition, frequencies of positive responses to recall antigens were also decreased in HTLV-infected individuals without spontaneous proliferation of PBMC. There was a polyclonal expansion of multiple T-cell receptor Vß families of CD4+ T lymphocytes in patients with spontaneous proliferation. We observed that HTLV-1 induced an immunosuppression characterized by a decrease in the stimulation index to a recall antigen, even in individuals who did not present spontaneous proliferation. On the other hand, only patients with PBMC presenting spontaneous proliferation showed polyclonal activation and increased proportion of CD4 T cells expressing CD45RO.

* Corresponding author. Mailing address: LASP/CPqGM/FIOCRUZ, Rua Waldemar Falcão, no. 121, Candeal, Salvador, Bahia CEP 40296-710, Brazil. Phone: 55 71-3356 8822. Fax: 55 71-3356 4320, ext. 300. E-mail: grassi{at}cpqgm.fiocruz.br.

Clinical and Vaccine Immunology, May 2006, p. 547-552, Vol. 13, No. 5
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.5.547-552.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Jerome, K. R. (2008). Viral Modulation of T-Cell Receptor Signaling. J. Virol. 82: 4194-4204 [Full Text]  


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