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 Previous Article

Clinical and Vaccine Immunology, April 2006, p. 530-533, Vol. 13, No. 4
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.4.530-533.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

ESAT-6 Peptide Recognition by Bovine CD8+ Lymphocytes of Naturally Infected Cows in Herds from Southern Italy

Fabrizio Vitale,1 Stefano Reale,1 Enrico Petrotta,1 Santo Caracappa,1 Annalisa Barera,2 Marco Pio La Manna,2 Pasquale Macaluso,2 Nadia Caccamo,2 Francesco Dieli,2 Hans Martin Vordermeier,3 Guido Sireci,2* and Alfredo Salerno2

Istituto Zooprofilattico Sperimentale della Sicilia, Via G. Marinuzzi 3, 90100 Palermo, Italia,1 Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italia,2 TB Research Group, Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom3

Received 9 December 2005/ Returned for modification 14 January 2006/ Accepted 16 February 2006

The aim of this study was to define epitopes of Mycobacterium bovis from ESAT-6 (early secretory antigen of 6 kDa) recognized by CD8+ T lymphocytes from cows naturally infected with Mycobacterium bovis. We found that bovine CD8+ T cells recognized 10 out of 11 ESAT-6 peptides tested.

* Corresponding author. Mailing address: Dipartimento di Biopatologia e Metodologie Biomediche, Università degli Studi di Palermo, Corso Tukory 211, 90100 Palermo, Italia. Phone: 39 091 6555939. Fax: 39 091 6555924. E-mail: sireci{at}unipa.it.

Clinical and Vaccine Immunology, April 2006, p. 530-533, Vol. 13, No. 4
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.4.530-533.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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