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Clinical and Vaccine Immunology, March 2006, p. 415-419, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.415-419.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Role of Macrophage Migration Inhibitory Factor in Hepatitis B Virus-Specific Cytotoxic-T-Lymphocyte-Induced Liver Injury

Kiminori Kimura,1,2* Masahito Nagaki,1 Jun Nishihira,3 Shinichi Satake,1 Kazuo Kuwata,2 and Hisataka Moriwaki1

First Department of Internal Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan,1 Department of Center for Emerging Infectious Diseases, Gifu University, Gifu-shi, Gifu 501-1194, Japan,2 Department of Research and Development, GeneticLab, 060-8638, Sapporo, Japan3

Received 17 September 2005/ Returned for modification 31 October 2005/ Accepted 8 December 2005

Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.

* Corresponding author. Mailing address: Center for Department of Emerging Infectious Diseases, Gifu University, 1-1 Yanagido, Gifu-shi Gifu 501-1194, Japan. Phone: 81-58-230-6146. Fax: 81-58-230-6144. E-mail: kkimura{at}cc.gifu-u.ac.jp.

Clinical and Vaccine Immunology, March 2006, p. 415-419, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.415-419.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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