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Clinical and Vaccine Immunology, March 2006, p. 319-328, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.319-328.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-{kappa}ß System

Madhavan P. Nair,* Supriya Mahajan, Jessica L. Reynolds, Ravikumar Aalinkeel, Harikrishnan Nair, Stanley A. Schwartz, and Chithan Kandaswami

Department of Medicine and Microbiology, Kaleida Health System, Buffalo General Hospital, State University of New York at Buffalo, Buffalo, New York 14203

Received 11 July 2005/ Returned for modification 11 August 2005/ Accepted 4 January 2006

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological effects remain to be clearly understood. We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-{alpha}) by human peripheral blood mononuclear cells (PBMC). Our results showed that quercetin significantly inhibited TNF-{alpha} production and gene expression in a dose-dependent manner. Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-{alpha} via modulation of NF-{kappa}ß1 and I{kappa}ß.

* Corresponding author. Mailing address: Department of Medicine, Division of Allergy, Immunology, and Rheumatology, 310 Multi Research Bldg., Buffalo General Hospital, 100 High Street, Buffalo, NY 14203. Phone: (716) 859-2985. Fax: (716) 859-2999. E-mail: mnair{at}acsu.buffalo.edu.

Clinical and Vaccine Immunology, March 2006, p. 319-328, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.319-328.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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