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Clinical and Vaccine Immunology, December 2006, p. 1358-1362, Vol. 13, No. 12
1071-412X/06/$08.00+0     doi:10.1128/CVI.00292-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Clostridium perfringens Antigens Recognized by Broiler Chickens Immune to Necrotic Enteritis{triangledown}

R. R. Kulkarni, V. R. Parreira, S. Sharif, and J. F. Prescott*

Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada

Received 17 August 2006/ Returned for modification 29 September 2006/ Accepted 16 October 2006

Little is known about immunity to necrotic enteritis (NE) in chickens. A recent study of broiler chickens showed that protection against NE was associated with infection-immunization with virulent but not with avirulent Clostridium perfringens.In the current study, six secreted antigenic proteins unique to virulent C. perfringens that reacted to serum antibodies from immune birds were identified by mass spectrophotometry; three of these proteins are part of the VirR-VirS regulon.

* Corresponding author. Mailing address: Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada. Phone: (519) 824-4120, ext. 54453. Fax: (519) 824-5930. E-mail: prescott{at}uoguelph.ca.

{triangledown} Published ahead of print on 25 October 2006.

Clinical and Vaccine Immunology, December 2006, p. 1358-1362, Vol. 13, No. 12
1071-412X/06/$08.00+0     doi:10.1128/CVI.00292-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chalmers, G., Bruce, H. L., Hunter, D. B., Parreira, V. R., Kulkarni, R. R., Jiang, Y.-F., Prescott, J. F., Boerlin, P. (2008). Multilocus Sequence Typing Analysis of Clostridium perfringens Isolates from Necrotic Enteritis Outbreaks in Broiler Chicken Populations. J. Clin. Microbiol. 46: 3957-3964 [Abstract] [Full Text]  
  • Kulkarni, R. R., Parreira, V. R., Sharif, S., Prescott, J. F. (2007). Immunization of Broiler Chickens against Clostridium perfringens-Induced Necrotic Enteritis. CVI 14: 1070-1077 [Abstract] [Full Text]  


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