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Clinical and Vaccine Immunology, November 2006, p. 1287-1290, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00269-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Compartmentalization of Interleukin-6 Response in a Patient with Septic Meningococcal Peritonitis{triangledown}

Alexandre Leite de Souza,1* Jaques Sztajnbok,1 Maristela Marques Salgado,2 Carla C. Romano,3 Maria das Graças Adelino Alkmin,2 Alberto J. S. Duarte,3 and Antonio Carlos Seguro1,4

Intensive Care Unit, Emílio Ribas Institute of Infectology, São Paulo, Brazil,1 Department of Immunology, Immunology and Microbiology Service, Adolfo Lutz Institute, São Paulo, Brazil,2 Department of Dermatology/LIM56, University of São Paulo School of Medicine, São Paulo, Brazil,3 Department of Nephrology, Laboratory of Basic Research, University of São Paulo School of Medicine, São Paulo, Brazil4

Received 20 July 2006/ Returned for modification 21 August 2006/ Accepted 30 August 2006

We report the first case of Neisseria meningitidis-induced septic peritonitis diagnosed by PCR assay of peritoneal fluid. Concentrations of interleukin-6 were notably higher in the peritoneal fluid than in the blood. PCR diagnosis of septic meningococcal peritonitis and the pathogenesis of the disease are discussed.

* Corresponding author. Mailing address: Rua da Consolação, 2270 Ap 304, CEP 01302-001, São Paulo, SP, Brasil. Phone: 55 11 3066 7292. Fax: 55 11 30882267. E-mail: alexandre{at}emilioribas.sp.gov.br.

{triangledown} Published ahead of print on 20 September 2006.

Clinical and Vaccine Immunology, November 2006, p. 1287-1290, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00269-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • de Souza, A. L., Seguro, A. C. (2008). Two centuries of meningococcal infection: from Vieusseux to the cellular and molecular basis of disease. J Med Microbiol 57: 1313-1321 [Abstract] [Full Text]  
  • de Souza, A. L., Sztajnbok, J., Salgado, M. M., Romano, C. C., Alkmin, M. d. G. A., Duarte, A. J. S., Seguro, A. C. (2007). Severe Myalgia of the Lower Extremities as the First Clinical Feature of Meningococcal Purpura Fulminans. Am J Trop Med Hyg 77: 723-726 [Abstract] [Full Text]  


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