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Clinical and Vaccine Immunology, October 2006, p. 1172-1174, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00181-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Cell-Mediated Immune Responses to Smallpox Vaccination

Sung-Han Kim,1 Sang-Gu Yeo,2 Jae-Hyun Cho,1 Hong-Bin Kim,1 Nam-Joong Kim,1 Myoung-don Oh,1 Kang-Won Choe,1 Youngmee Jee,2* and Haewol Cho2

Department of Internal Medicine, Seoul National University College of Medicine,1 Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, National Institute of Health, Seoul, Republic of Korea2

Received 12 April 2006/ Returned for modification 22 June 2006/ Accepted 28 July 2006

We report that vaccine dilution (1:1 or 1:10) and previous vaccinia virus vaccination status had no significant effect on cell-mediated immune responses (i.e., the immediate vaccinia virus-specific gamma interferon-producing T-cell response measured by enzyme-linked immunospot assay) 1 month after smallpox vaccination (Lancy-Vaxina; Berna Biotech, Switzerland).

* Corresponding author. Mailing address: Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, National Institute of Health, 5 Nokbun-dong, Eunpyung-gu, Seoul 122-701, Republic of Korea. Phone: 82-2-380-1494. Fax: 82-2-380-1495. E-mail: ymeejee{at}nih.go.kr.

Clinical and Vaccine Immunology, October 2006, p. 1172-1174, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00181-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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