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Clinical and Vaccine Immunology, October 2006, p. 1137-1142, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00125-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Identification and Characterization of a Major Cell Wall-Associated Iron-Regulated Envelope Protein (Irep-28) in Mycobacterium tuberculosis

Veena C. Yeruva,1 Sridevi Duggirala,1 V. Lakshmi,2 Daniel Kolarich,3 Friedrich Altmann,3 and Manjula Sritharan1*

School of Life Sciences, University of Hyderabad, Hyderabad, India,1 Department of Microbiology, Nizams Institute of Medical Sciences, Hyderabad, India,2 Department of Chemistry, Universitat fur Bodenkultur Wien, Vienna, Austria3

Received 18 March 2006/ Returned for modification 13 June 2006/ Accepted 26 July 2006

Iron limitation and the expression of mycobactin and carboxymycobactin by Mycobacterium tuberculosis are known. Here, we report how iron regulated the coordinate expression of these two siderophores and a 28-kDa cell wall-associated iron-regulated protein (Irep-28). Irep-28 is identified as the DNA-binding HU homologue HupB protein (hupB [Rv2986c]). Antibodies to this protein were detected in sera from tuberculosis patients. The location of the protein in the cell wall makes it a potential drug target.

* Corresponding author. Mailing address: Department of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad-500 046, India. Phone: 091-40-23011763. Fax: 091-40-23010120. E-mail: srimanju{at}yahoo.com.

Clinical and Vaccine Immunology, October 2006, p. 1137-1142, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00125-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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