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Clinical and Vaccine Immunology, January 2006, p. 156-159, Vol. 13, No. 1
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.1.156-159.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Human Endotoxemia Induces Down-Regulation of Monocyte CC Chemokine Receptor 2

Michael Heesen,1* Rosemarijn Renckens,2 Alex F. de Vos,2 Dagmar Kunz,3 and Tom van der Poll2

Department of Anesthesia, Bamberg Hospital and University Hospital Aachen, Bamberg, Germany,1 Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands,2 Department of Clinical Chemistry, DRK-Kliniken, Neuwied, Germany3

Received 20 June 2005/ Returned for modification 29 July 2005/ Accepted 25 August 2005

Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively.

* Corresponding author. Mailing address: Department of Anesthesia, Klinikum Bamberg, Buger Str. 80, 96049 Bamberg, Germany. Phone: 49-951-503-3001. Fax: 49-951-503-3005. E mail: michael.heesen{at}sozialstiftung-bamberg.de.

Clinical and Vaccine Immunology, January 2006, p. 156-159, Vol. 13, No. 1
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.1.156-159.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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  • Bahador, M., Cross, A. S. (2007). Review: From therapy to experimental model: a hundred years of endotoxin administration to human subjects. Innate Immunity 13: 251-279 [Abstract]  


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