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Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1130-1134, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1130-1134.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Difference in Cytokine Production and Cell Activation between Adenoidal Lymphocytes and Peripheral Blood Lymphocytes of Children with Otitis Media

Atsushi Harimaya,1* Jussi Tarkkanen,2 Petri Mattila,3 Nobuhiro Fujii,4 Jukka Ylikoski,3 and Tetsuo Himi1

Department of Otolaryngology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan,1 Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, HUCH 00029, Finland,2 Department of Otorhinolaryngology, Helsinki University Central Hospital, Helsinki, HUCH 00029, Finland,3 Department of Microbiology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido 060-8543, Japan4

Received 17 January 2005/ Returned for modification 26 April 2005/ Accepted 1 June 2005

We evaluated the immunological potential of adenoidal lymphocytes from children with recurrent otitis media. Interleukin-4 release and CD69 expression were lower in adenoidal lymphocytes than in peripheral blood lymphocytes (PBL). Our results suggest that there may be a difference between the immunological potential of adenoidal lymphocytes and that of PBL in children with otitis.

* Corresponding author. Mailing address: Department of Otolaryngology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan. Phone: 81-11-611-2111, ext. 3491. Fax: 81-11-615-5405. E-mail: harimaya{at}sapmed.ac.jp.

Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1130-1134, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1130-1134.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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