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Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1123-1126, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1123-1126.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Utilization of Follow-Up Specimens from Viremic Blood Donors To Assess the Value of West Nile Virus Immunoglobulin G Avidity as an Indicator of Recent Infection

Harry E. Prince,1* Mary Lapé-Nixon,1 Michael P. Busch,2 Leslie H. Tobler,2 Gregory A. Foster,3 and Susan L. Stramer3

Focus Diagnostics, Cypress, California,1 Blood Systems Research Institute, San Francisco, California,2 American Red Cross Blood Services, Gaithersburg, Maryland3

Received 21 April 2005/ Returned for modification 24 May 2005/ Accepted 15 June 2005

The value of West Nile virus immunoglobulin G avidity for distinguishing recent from past infection was investigated using 348 follow-up specimens from 170 viremic blood donors. Low avidity accurately indicated infection within the previous 4 months. However, due to rapid avidity maturation in some individuals, high avidity did not accurately indicate past infection.

* Corresponding author. Mailing address: Focus Diagnostics, 5785 Corporate Avenue, Cypress, CA 90630. Phone: (714) 503-2047. Fax: (714) 484-1296. E-mail: hprince{at}focusdx.com.

Clinical and Diagnostic Laboratory Immunology, September 2005, p. 1123-1126, Vol. 12, No. 9
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.9.1123-1126.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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