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Clinical and Diagnostic Laboratory Immunology, August 2005, p. 1003-1005, Vol. 12, No. 8
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.8.1003-1005.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Patterns of CD8 T-Cell Epitopes within the Human Papillomavirus Type 16 (HPV 16) E6 Protein among Young Women Whose HPV 16 Infection Has Become Undetectable

Departments of Dermatology,¹ Pathology,² Microbiology and ImmunologyUniversity of Arkansas for Medical Sciences, Little Rock, Arkansas 72205,³ Department of Pediatrics, Schools of Medicine, University of California at San Francisco, San Francisco, California 94143⁴

Received 25 January 2005/ Returned for modification 11 March 2005/ Accepted 27 April 2005

The patterns of CD8 T-cell epitopes recognized within the E6 protein in women who had cleared their human papillomavirus 16 infection were examined. T-cell lines were established using autologous dendritic cells infected with a recombinant vaccinia virus. Evidence of potential antigenic epitopes was shown in 8 of 23 (34.8%) women.