CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nardelli, D. T.
Right arrow Articles by Schell, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nardelli, D. T.
Right arrow Articles by Schell, R. F.

 Previous Article  |  Next Article 

Clinical and Diagnostic Laboratory Immunology, June 2005, p. 786-792, Vol. 12, No. 6
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.6.786-792.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

CD4+ CD25+ T Cells Prevent Arthritis Associated with Borrelia Vaccination and Infection

Dean T. Nardelli,1,2 Joseph P. Cloute,1,3 K. H. Kevin Luk,1,3 Jose Torrealba,5,6 Thomas F. Warner,7 Steven M. Callister,8 and Ronald F. Schell1,2,3,4*

Wisconsin State Laboratory of Hygiene,1 Departments of Comparative Biomedical Sciences,2 Bacteriology,3 Medical Microbiology and Immunology,4 Pathology and Laboratory Medicine,5 Surgery, University of Wisconsin,6 Department of Pathology, Veterans Administration Hospital, Madison,7 Microbiology Research Laboratory and Section of Infectious Diseases, Gundersen Lutheran Medical Center, La Crosse, Wisconsin8

Received 7 January 2005/ Returned for modification 10 March 2005/ Accepted 18 March 2005

CD4+ CD25+ T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4+ CD25+ T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4+ CD25+ T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals.

* Corresponding author. Mailing address: University of Wisconsin, Wisconsin State Laboratory of Hygiene, 465 Henry Mall, Madison, WI 53706. Phone: (608) 262-3634. Fax: (608) 265-3451. E-mail: RFSchell{at}facstaff.wisc.edu.

Clinical and Diagnostic Laboratory Immunology, June 2005, p. 786-792, Vol. 12, No. 6
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.6.786-792.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:



Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2005 by the American Society for Microbiology. All rights reserved.