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Clinical and Diagnostic Laboratory Immunology, March 2005, p. 375-379, Vol. 12, No. 3
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.3.375-379.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Placental Malaria Diminishes Development of Antibody Responses to Plasmodium falciparum Epitopes in Infants Residing in an Area of Western Kenya Where P. falciparum Is Endemic

Phillip Cullison Bonner,1 Zhiyong Zhou,1,2 Lisa B. Mirel,1 John G. Ayisi,3 Ya Ping Shi,1,3 Anna M. van Eijk,3 Juliana A. Otieno,4 Bernard L. Nahlen,5 Richard W. Steketee,1 and Venkatachalam Udhayakumar1*

Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services,1 Atlanta Research and Education Foundation, Atlanta, Georgia,2 Center for Vector Biology and Control Research, Kenya Medical Research Institute,3 Ministry of Health, New Nyanza Provincial Hospital, Kisumu, Kenya,4 Roll Back Malaria, World Health Organization, Geneva, Switzerland5

Received 22 September 2004/ Returned for modification 22 October 2004/ Accepted 4 January 2005

To determine the effect of placental malaria (PM) infection on the development of antibody responses to malaria in infants, we measured immunoglobulin G levels to seven different Plasmodium falciparum epitopes by using plasma samples collected at monthly intervals from infants born to mothers with and without PM. Overall, PM was associated with diminished antibody levels to all of the epitopes tested, especially with infants aged ≥4 to 12 months, and the difference was statistically significant for four of the seven epitopes (P < 0.0035). These findings suggest that PM can negatively influence the development of immune responses to malaria in infants.

* Corresponding author. Mailing address: Malaria Branch, Division of Parasitic Diseases, NCID, Centers for Disease Control and Prevention, Mail Stop F-12, 4770 Buford Highway, Chamblee, GA 30341. Phone: (770) 488-4047. Fax: (770) 488-4454. E-mail: vxu0{at}cdc.gov.

Clinical and Diagnostic Laboratory Immunology, March 2005, p. 375-379, Vol. 12, No. 3
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.3.375-379.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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