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Clinical and Diagnostic Laboratory Immunology, February 2005, p. 361-362, Vol. 12, No. 2
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.2.361-362.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antibody Responses to Asian and American Genotypes of Dengue 2 Virus in Immunized Mice

Lidice Bernardo, Adriana Yndart, Susana Vázquez, Luis Morier, and María G. Guzmán*

Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, "Pedro Kourí" Tropical Medicine Institute, Autopista Novia del Mediodía, Havana, Cuba

Received 28 June 2004/ Returned for modification 21 September 2004/ Accepted 17 November 2004

The possibility of a correlation between dengue virus genotype groups and disease severity is currently under discussion. The objective of this investigation was to identify any immunogenic difference between the American and Asian dengue 2 virus genotypes through the study of antibody development (virus-binding immunoglobulin G and neutralizing antibodies) in mice. Differences in the neutralization pattern between the strains studied were observed, suggesting the presence of slight antigenic variations among them. The lack of recognition of one of the Asian genotype strains was remarkable.

* Corresponding author. Mailing address: Virology Department, PAHO/WHO Collaborating Center for Viral Diseases, "Pedro Kourí" Tropical Medicine Institute, Autopista Novia del Mediodía, Km 6, P.O. Box Marianao 13, Havana, Cuba. Phone: 53-7-2020450 and -2020633. Fax: 53-7-2046051. E-mail: lupe{at}ipk.sld.cu.

Clinical and Diagnostic Laboratory Immunology, February 2005, p. 361-362, Vol. 12, No. 2
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.2.361-362.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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