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Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1340-1342, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1340-1342.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Immunogenicity of Fowlpox Virus Expressing the Avian Influenza Virus H5 Gene (TROVAC AIV-H5) in Cats

Kemal Karaca,1* David E. Swayne,2 Deborah Grosenbaugh,1 Michel Bublot,3 Amy Robles,1 Erica Spackman,2 and Robert Nordgren1

Merial Ltd., Athens, Georgia,1 Southeastern Poultry Research Laboratory, Athens, Georgia,2 Merial SAS, Lyon, France3

Received 2 June 2005/ Returned for modification 11 July 2005/ Accepted 5 August 2005

Vaccination of cats with fowlpox virus expressing the avian influenza (AI) virus H5 hemagglutinin gene (TROVAC AI) resulted in detectable hemagglutination inhibition (HI) antibody responses to the homologous A/Turkey/Ireland/1378/83 (H5N8) (A/tky/Ire/83) AI virus antigen. The HI antibody responses to heterologous A/Chicken/Indonesia/7/03 (H5N1) (A/ck/Indonesia/03) AI virus antigen were also detected in all vaccinated cats, but only after booster vaccinations. The vaccine described in this study and other poxvirus-vectored vaccines may be of value for the prophylaxis of AI virus-associated morbidity and mortality in mammals.

* Corresponding author. Mailing address: Merial Ltd., 115 Transtech Drive, Athens, GA 30601. Phone: (706) 552-2435. Fax: (706) 543-1667. E-mail: Kemal.karaca{at}merial.com.

Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1340-1342, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1340-1342.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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