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Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1336-1339, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1336-1339.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Isolation and Characterization of the Promoter and Partial Enhancer Region of the Porcine Inter-{alpha}-Trypsin Inhibitor Heavy Chain 4 Gene

Niamh Harraghy* and Timothy J. Mitchell

Institute of Biomedical and Life Sciences, Division of Infection and Immunity, University of Glasgow, Glasgow G12 8QQ, United Kingdom

Received 17 June 2005/ Returned for modification 28 July 2005/ Accepted 18 August 2005

A porcine genomic library was screened for clones containing the promoter of the major acute-phase protein in pigs, inter-{alpha}-trypsin heavy chain 4 (ITIH4). Following isolation of the promoter, a functional analysis was performed with Hep3B cells. The promoter was induced by interleukin-6 (IL-6) but not by IL-1ß. However, IL-1ß was shown to inhibit the IL-6-induced activation of the porcine ITIH4 promoter.

* Corresponding author. Present address: Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Building 43, D-66421 Homburg/Saar, Germany. Phone: 49 6841 1623900. Fax: 49 6841 1623985. E-mail: bhnhar{at}uniklinik-saarland.de.

Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1336-1339, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1336-1339.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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