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Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1331-1333, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1331-1333.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Immunoglobulin G({kappa}) [IgG({kappa})] and IgG({lambda}) Paraproteinemia in a Child with AIDS and Response to Highly Active Antiretroviral Therapy

Filiz Odabasi Seeborg,1* Hannah Gay,2 Lorenz M. Schmiege III,3 David Bernard,4 and William T. Shearer1

Section of Allergy & Immunology, Texas Children's Hospital and Baylor College of Medicine,1 Department of Pathology, Baylor College of Medicine, Houston, Texas 77030,3 Pediatric Infectious Disease Division, University of Mississippi Medical Center, Jackson, Mississippi 39213,2 Department of Pathology, The Methodist Hospital, Houston, Texas 77030, and Weill Medical College of Cornell University, New York, New York 100214

Received 5 August 2004/ Returned for modification 29 November 2004/ Accepted 13 September 2005

We report an 8-year-old boy with AIDS, extremely elevated serum immunoglobulin G (IgG) concentration and IgG kappa [IgG({kappa})] and IgG lambda [IgG({lambda})] paraproteinemia. This paraproteinemia partially responded to highly active antiretroviral therapy. This case emphasizes the importance of controlling B-cell activation.

* Corresponding author. Mailing address: Texas Children's Hospital, 6621 Fannin Street (MC; FC330.01), Houston, TX 77030. Phone: (832) 824-1274. Fax: (832) 825-7131. E-mail: fodabasi{at}hotmail.com.

Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1331-1333, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1331-1333.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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