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Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1275-1279, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1275-1279.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Alterations of Natural Killer Cell and T-Lymphocyte Counts in Adults Infected with Human Immunodeficiency Virus through Blood and Plasma Sold in the Past in China and in Whom Infection Has Progressed Slowly over a Long Period

Yongjun Jiang, Hong Shang,* Zining Zhang, Yingying Diao, Di Dai, Wenqing Geng, Min Zhang, Xiaoxu Han, Yanan Wang, and Jing Liu

Department of Laboratory Medicine, First Affiliated Hospital, China Medical University, Shenyang 110001, People’s Republic of China

Received 23 March 2005/ Returned for modification 6 May 2005/ Accepted 3 August 2005

Natural killer (NK) cells, natural killer T (NKT) cells, and T lymphocytes were analyzed by using a flow cytometer in 225 human immunodeficiency virus (HIV)-positive individuals infected through the past sale of blood and plasma without receiving antiretroviral therapy in the People’s Republic of China. According to CD4 T-cell counts these HIV-infected adults were stratified into three groups: long-term slow progressors, HIV-infected subjects, and AIDS patients. NK cell counts in long-term slow progressors were higher compared to HIV infection and AIDS patients (P < 0.05) and lower compared to normal controls (P < 0.05), whereas NKT cell counts in slow progressors and the HIV infection group were not different from those of normal controls. NK cell counts in HIV-seropositive subjects were positively correlated with CD4 T-cell counts (P < 0.05), and NKT cell counts were positively correlated with CD4 T-cell and CD8 T-cell counts (P < 0.05). The CD8 T-cell counts were higher in slow progressors compared to those with HIV infection, AIDS patients, and normal controls. These results indicated that HIV infection causes alterations of NK cells and T cells in slow progressors, HIV-infected subjects, and AIDS patient groups, but no difference was found in NKT cell counts and percentages in slow progressors and the HIV-infected group compared to normal controls.

* Corresponding author. Mailing address: Department of Laboratory Medicine, First Affiliated Hospital, China Medical University, N0.155, Nanjing North St., Heping District, Shenyang, 110001, P. R. China. Phone: (86) 24-23254254. Fax: (86) 24-23254254. E-mail: p3lab{at}yeah.net.

Clinical and Diagnostic Laboratory Immunology, November 2005, p. 1275-1279, Vol. 12, No. 11
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.11.1275-1279.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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