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Clinical and Diagnostic Laboratory Immunology, November 2004, p. 1192-1193, Vol. 11, No. 6
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.6.1192-1193.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Biased Immunoglobulin G (IgG) Subclass Production in a Case of Hyper-IgM Syndrome

G. R. McLean,1* K. K. Miller,2 J. W. Schrader,1 and A. K. Junker2*

The Biomedical Research Centre, University of British Columbia,1 Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada2

Received 26 July 2004/ Returned for modification 20 August 2004/ Accepted 9 September 2004

Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare heterogeneous primary immune deficiency. We describe a patient with HIGM characterized by skewed production of serum IgG subclasses and normal somatic hypermutation. This case may represent a subgroup of HIGM type 4 that is characterized by a biased switching to the V-region proximal constant regions.

* Corresponding author. Mailing address for G. R. McLean: The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3. Phone: (604) 822-7714. Fax: (604) 822-7815. E-mail: gmclean{at}brc.ubc.ca. Mailing address for A. K. Junker: Division of Infectious & Immunological Diseases, BC Children's Hospital, Room K4-223, 4480 Oak St., Vancouver, BC, Canada V5H 3V4. Phone: (604) 875-3591. Fax: (604) 875-2414. E-mail: ajunker{at}cw.bc.ca.

Clinical and Diagnostic Laboratory Immunology, November 2004, p. 1192-1193, Vol. 11, No. 6
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.6.1192-1193.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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