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Clinical and Diagnostic Laboratory Immunology, November 2004, p. 1185-1188, Vol. 11, No. 6
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.6.1185-1188.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Age-Dependent Accuracy of Helicobacter pylori Antibody Assays for Adults, with Special Emphasis on Atrophic Gastritis

A. Salomaa-Räsänen,1,2* T. U. Kosunen,1 J. Mattila,3 S. Sarna,4 and H. Rautelin1,5

Department of Bacteriology and Immunology, Haartman Institute,1 Department of Public Health, University of Helsinki,4 Department of Microbiology, HUSLAB, Helsinki University Central Hospital, Helsinki,5 Vammala Health Center, Vammala,2 Department of Pathology, Tampere University Hospital, Tampere, Finland3

Received 8 June 2004/ Returned for modification 19 July 2004/ Accepted 8 September 2004

The accuracy of Helicobacter pylori antibody assays for 561 consecutive adult outpatients who had undergone gastroscopy was studied. The sensitivity of an immunoglobulin G test was 99 to 100% for all age groups, but the specificity declined by age group, from 99% for those aged 15 to 49 years to 75% for those aged ≥65 years. The exclusion of false-positive results for patients with atrophic gastritis improved the specificity to 93 to 97% for the older age groups.

* Corresponding author. Mailing address: Department of Bacteriology and Immunology, Haartman Institute, P.O. Box 21 (Haartmaninkatu 3), FIN-00014 University of Helsinki, Helsinki, Finland. Phone: 358-9-19126296. Fax: 358-9-19126382. E-mail: anniina.salomaa{at}helsinki.fi.

Clinical and Diagnostic Laboratory Immunology, November 2004, p. 1185-1188, Vol. 11, No. 6
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.6.1185-1188.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.





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